注射型磷酸鈣骨水泥/纖維蛋白膠作為BMP注射性載體的可行性研究

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注射型磷酸鈣骨水泥/纖維蛋白膠作為BMP注射性載體的可行性研究
作者:劉通方,劉建,孟國林,袁志,呂榮,畢龍,王登虎,劉豔武,胡蘊玉
【關鍵詞】 注射劑;磷酸鈣類;骨粘合劑;纖維蛋白組織粘著劑;骨形態發生蛋白質類;載體;骨誘導
  【Abstract】 AIM: To evaluate the feasibility of injectable calcium phosphate cement (ICPC) and fibrin sealant (FS) as an injectable compound carrier of bone morphogenic protein (BMP) . METHODS: The composites of ICPC/FS/bBMP, ICPC/FS or bBMP were injected subcutanously or implanted into thigh muscle pouches of 45 mice at effect of ecto RESULTS: ICPC/FS/bBMP composite induced the formation of new bone most effectively. BBMP stimulated cess osteogenesis while ICPC/FS showed no sign of new bone e was a significant difference among them (P